Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome

Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of recurrence following resection or disease progression beyond kinase mutation are poorly understood. Utilizing chromatin immunoprecipitation with...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hemming, Matthew L., Lawlor, Matthew A., Zeid, Rhamy, Lesluyes, Tom, Fletcher, Jonathan A., Raut, Chandrajit P., Sicinska, Ewa T., Chibon, Frédéric, Armstrong, Scott A., Demetri, George D., Bradner, James E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016782/
https://ncbi.nlm.nih.gov/pubmed/29866822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802079115
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