Protein Kinase C Theta (PKCθ) Regulates KIT Expression and Proliferation in Gastrointestinal Stromal Tumors

Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA kinase inhibitor, imatinib, is standard of care for patients with metastatic GIST. However, most of these patients eventually develop clinical...

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Bibliographische Detailangaben
Hauptverfasser: Ou, Wen-bin, Zhu, Mei-jun, Demetri, George D., Fletcher, Christopher DM, Fletcher, Jonathan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811224/
https://ncbi.nlm.nih.gov/pubmed/18521081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.177
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