Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours

BACKGROUND: Most gastrointestinal stromal tumours (GIST) are driven by activating oncogenic mutations of KIT/PDGFRA, which provide a compelling therapeutic target. Our previous studies showed that CDC37, regulated by casein kinase 2 (CK2), is a crucial HSP90 cofactor for KIT oncogenic function and a...

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Udgivet i:Br J Cancer
Main Authors: Huang, Mengyuan, Yang, Wenyu, Zhu, Jiaqing, Mariño-Enríquez, Adrián, Zhu, Chennianci, Chen, Jiaming, Wu, Yuehong, Quan, Yanping, Qiu, Haibo, Li, Xuhui, Chai, Li, Fletcher, Jonathan A., Ou, Wen-Bin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000686/
https://ncbi.nlm.nih.gov/pubmed/31776458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0657-5
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