Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression

Oncogenic KIT or PDGFRA receptor tyrosine kinase (TK) mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA kinase inhibitor, imatinib, is the standard of care for patients with metastatic GIST. However, approximately 10% of KIT-positive GIST met...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Tu, Yuqing, Zuo, Rui, Ni, Nan, Eilers, Grant, Wu, Duolin, Pei, Yuting, Nie, Zuoming, Wu, Yeqing, Wu, Yuehong, Ou, Wen-Bin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300111/
https://ncbi.nlm.nih.gov/pubmed/30488756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1553335
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