Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo

Small interfering RNAs (siRNAs) are short, double-stranded RNAs that use the endogenous RNAi pathway to mediate gene silencing. Phosphorylation facilitates loading of a siRNA into the Ago2 complex and subsequent cleavage of the target mRNA. In this study, 2′, 3′ seco nucleoside modifications, which...

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Main Authors: Kenski, Denise M., Cooper, Abby J., Li, Jenny J., Willingham, Aarron T., Haringsma, Henry J., Young, Tracy A., Kuklin, Nelly A., Jones, Jeffrey J., Cancilla, Mark T., McMasters, Daniel R., Mathur, Melina, Sachs, Alan B., Flanagan, W. Michael
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811019/
https://ncbi.nlm.nih.gov/pubmed/19917641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp913
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