BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism

Juvenile hemochromatosis is an iron overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP)1 and hemojuvelin (HFE2)2. We have previously shown that hemojuvelin is a bone morphogenetic protein (BMP) co-receptor and that BMP signals regulate hepcid...

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Главные авторы: Andriopoulos, Billy, Corradini, Elena, Xia, Yin, Faasse, Sarah A., Chen, Shanzhuo, Grgurevic, Lovorka, Knutson, Mitchell D., Pietrangelo, Antonello, Vukicevic, Slobodan, Lin, Herbert Y., Babitt, Jodie L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810136/
https://ncbi.nlm.nih.gov/pubmed/19252486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.335
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