BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism

Juvenile hemochromatosis is an iron overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP)1 and hemojuvelin (HFE2)2. We have previously shown that hemojuvelin is a bone morphogenetic protein (BMP) co-receptor and that BMP signals regulate hepcid...

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Bibliografiske detaljer
Main Authors: Andriopoulos, Billy, Corradini, Elena, Xia, Yin, Faasse, Sarah A., Chen, Shanzhuo, Grgurevic, Lovorka, Knutson, Mitchell D., Pietrangelo, Antonello, Vukicevic, Slobodan, Lin, Herbert Y., Babitt, Jodie L.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810136/
https://ncbi.nlm.nih.gov/pubmed/19252486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.335
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