Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

Mutations in transmembrane protease, serine 6 (TMPRSS6), encoding matriptase-2, are responsible for the familial anemia disorder iron-refractory iron deficiency anemia (IRIDA). Patients with IRIDA have inappropriately elevated levels of the iron regulatory hormone hepcidin, suggesting that TMPRSS6 i...

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Autori principali: Meynard, Delphine, Vaja, Valentina, Sun, Chia Chi, Corradini, Elena, Chen, Shanzhuo, López-Otín, Carlos, Grgurevic, Lovorka, Hong, Charles C., Stirnberg, Marit, Gütschow, Michael, Vukicevic, Slobodan, Babitt, Jodie L., Lin, Herbert Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142910/
https://ncbi.nlm.nih.gov/pubmed/21622652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-348698
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