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Triazole inhibitors of Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase
Cryptosporidium parvum is an important human pathogen and potential bioterrorism agent. This protozoan parasite cannot salvage guanine or guanosine and therefore relies on inosine 5′-monophosphate dehydrogenase (IMPDH) for biosynthesis of guanine nucleotides and hence for survival. Since C. parvum I...
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| Huvudupphovsmän: | , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810100/ https://ncbi.nlm.nih.gov/pubmed/19624136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900410u |
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