Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

TDP-43 is an RNA/DNA-binding protein implicated in transcriptional repression and mRNA processing. Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis. Besides aggregation of TDP-43, loss of nuclear localization is observed in disease. To identify relevant...

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Main Authors: Fiesel, Fabienne C, Voigt, Aaron, Weber, Stephanie S, Van den Haute, Chris, Waldenmaier, Andrea, Görner, Karin, Walter, Michael, Anderson, Marlene L, Kern, Jeannine V, Rasse, Tobias M, Schmidt, Thorsten, Springer, Wolfdieter, Kirchner, Roland, Bonin, Michael, Neumann, Manuela, Baekelandt, Veerle, Alunni-Fabbroni, Marianna, Schulz, Jörg B, Kahle, Philipp J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808372/
https://ncbi.nlm.nih.gov/pubmed/19910924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.324
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