UBE2E Ubiquitin-conjugating Enzymes and Ubiquitin Isopeptidase Y Regulate TDP-43 Protein Ubiquitination

Trans-activation element DNA-binding protein of 43 kDa (TDP-43) characterizes insoluble protein aggregates in distinct subtypes of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. TDP-43 mediates many RNA processing steps within distinct protein complexes. Here we identify novel...

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Autori principali: Hans, Friederike, Fiesel, Fabienne C., Strong, Jennifer C., Jäckel, Sandra, Rasse, Tobias M., Geisler, Sven, Springer, Wolfdieter, Schulz, Jörg B., Voigt, Aaron, Kahle, Philipp J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081952/
https://ncbi.nlm.nih.gov/pubmed/24825905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.561704
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