Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

TDP-43 is an RNA/DNA-binding protein implicated in transcriptional repression and mRNA processing. Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis. Besides aggregation of TDP-43, loss of nuclear localization is observed in disease. To identify relevant...

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Detalhes bibliográficos
Main Authors: Fiesel, Fabienne C, Voigt, Aaron, Weber, Stephanie S, Van den Haute, Chris, Waldenmaier, Andrea, Görner, Karin, Walter, Michael, Anderson, Marlene L, Kern, Jeannine V, Rasse, Tobias M, Schmidt, Thorsten, Springer, Wolfdieter, Kirchner, Roland, Bonin, Michael, Neumann, Manuela, Baekelandt, Veerle, Alunni-Fabbroni, Marianna, Schulz, Jörg B, Kahle, Philipp J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808372/
https://ncbi.nlm.nih.gov/pubmed/19910924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.324
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