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TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

BACKGROUND: Trans-activation response element (TAR) DNA binding protein of 43kDa (TDP-43) is causally related to the neurodegenerative diseases frontotemporal dementia and amyotrophic lateral sclerosis being the hallmark protein in the disease-characteristic neuropathological lesions and via genetic...

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Autors principals: Fiesel, Fabienne C, Schurr, Christine, Weber, Stephanie S, Kahle, Philipp J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170629/
https://ncbi.nlm.nih.gov/pubmed/21878116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-64
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