TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity

Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The relative impacts of TDP-43 alteration, mutation, or inherent protein function on ne...

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Detalhes bibliográficos
Main Authors: Voigt, Aaron, Herholz, David, Fiesel, Fabienne C., Kaur, Kavita, Müller, Daniel, Karsten, Peter, Weber, Stephanie S., Kahle, Philipp J., Marquardt, Till, Schulz, Jörg B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923622/
https://ncbi.nlm.nih.gov/pubmed/20806063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012247
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