Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Activation of p53 by murine double minute (MDM2) antagonist nutlin-3a or inhibition of X-linked inhibitor of apoptosis (XIAP) induces apoptosis in acute myeloid leukemia (AML) cells. We demonstrate that concomitant inhibition of MDM2 by nutlin-3a and of XIAP by small molecule antagonists synergistic...

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Main Authors: Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., Koller, Erich, Pinilla, Clemencia, Vassilev, Lyubomir T., Reed, John C., Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808154/
https://ncbi.nlm.nih.gov/pubmed/19897582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-212563
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