Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B(2) receptor antagonism in human synovial fibroblasts

BACKGROUND AND PURPOSE: Bradykinin (BK) and B(2) receptors have been implicated in the pathophysiology of osteoarthritis (OA), and synovitis is one of its hallmarks. Here, the selective B(2) receptor antagonists MEN16132 and icatibant have been pharmacologically characterized in human synovial cells...

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Detalhes bibliográficos
Main Authors: Bellucci, F, Cucchi, P, Catalani, C, Giuliani, S, Meini, S, Maggi, CA
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807661/
https://ncbi.nlm.nih.gov/pubmed/20050188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00511.x
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