Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human Endothelial Cells by Quenching the NF-kB Pathway Activation

BACKGROUND: Bradykinin (BK) induces angiogenesis by promoting vessel permeability, growth and remodeling. This study aimed to demonstrate that the B2R antagonist, fasitibant, inhibits the BK pro-angiogenic effects. METHODOLOGY: We assesed the ability of fasibitant to antagonize the BK stimulation of...

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Autores principales: Terzuoli, Erika, Meini, Stefania, Cucchi, Paola, Catalani, Claudio, Cialdai, Cecilia, Maggi, Carlo Alberto, Giachetti, Antonio, Ziche, Marina, Donnini, Sandra
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879294/
https://ncbi.nlm.nih.gov/pubmed/24392129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084358
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