Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

TP53 mutation occurs in 50–75% of human pancreatic ductal adenocarcinomas (PDAC) following an initiating activating mutation in the KRAS gene. These p53 mutations frequently result in expression of a stable protein, p53(R175H), rather than complete loss of protein expression. In this study we elucid...

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Autors principals: Morton, Jennifer P., Timpson, Paul, Karim, Saadia A., Ridgway, Rachel A., Athineos, Dimitris, Doyle, Brendan, Jamieson, Nigel B., Oien, Karin A., Lowy, Andrew M., Brunton, Valerie G., Frame, Margaret C., Evans, T. R. Jeffry, Sansom, Owen J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806749/
https://ncbi.nlm.nih.gov/pubmed/20018721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908428107
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