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Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-dependent pathway and the generation of A/T mutations by the Msh2/ubiquitinated...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806606/ https://ncbi.nlm.nih.gov/pubmed/19901081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091707 |
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