HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase

DNA damage tolerance is regulated at least in part at the level of proliferating cell nuclear antigen (PCNA) ubiquitination. Monoubiquitination (PCNA-Ub) at lysine residue 164 (K164) stimulates error-prone translesion synthesis (TLS), Rad5-dependent polyubiquitination (PCNA-Ub(n)) stimulates error-f...

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Autors principals: Krijger, Peter H.L., Lee, Kyoo-Young, Wit, Niek, van den Berka, Paul C.M., Wu, Xiaoli, Roest, Henk P., Maas, Alex, Ding, Hao, Hoeijmakers, Jan H.J., Myung, Kyungjae, Jacobs, Heinz
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381732/
https://ncbi.nlm.nih.gov/pubmed/21269891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.12.008
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