Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these arrested forks. In yeast, one branch of PRR involves proliferating cell nuclear antigen (PCNA) polyubiquitin...

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Detalhes bibliográficos
Main Authors: Motegi, Akira, Liaw, Hung-Jiun, Lee, Kyoo-Young, Roest, Henk P., Maas, Alex, Wu, Xiaoli, Moinova, Helen, Markowitz, Sanford D., Ding, Hao, Hoeijmakers, Jan H. J., Myung, Kyungjae
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518831/
https://ncbi.nlm.nih.gov/pubmed/18719106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805685105
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