Cargando...
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
Mono-ubiquitination of Fancd2 is essential for repairing DNA inter-strand crosslinks (ICLs) but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL repair, is recruited to ICLs by ubiquitinated (Ub)-Fancd2. This could in principle explain how Ub-Fancd2 promotes ICL repair...
Guardado en:
| Publicado en: | Science |
|---|---|
| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4770513/ https://ncbi.nlm.nih.gov/pubmed/26797144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5634 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|