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Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
Mono-ubiquitination of Fancd2 is essential for repairing DNA inter-strand crosslinks (ICLs) but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL repair, is recruited to ICLs by ubiquitinated (Ub)-Fancd2. This could in principle explain how Ub-Fancd2 promotes ICL repair...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4770513/ https://ncbi.nlm.nih.gov/pubmed/26797144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5634 |
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