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RADX prevents genome instability by confining replication fork reversal to stalled forks
RAD51 facilitates replication fork reversal and protects reversed forks from nuclease degradation. While potentially a useful replication stress response mechanism, unregulated fork reversal can cause genome instability. Here we show that RADX, a single-strand DNA binding protein that binds to and d...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8286330/ https://ncbi.nlm.nih.gov/pubmed/34107305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.014 |
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