RADX controls RAD51 filament dynamics to regulate replication fork stability

The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly regulated since both too little and too much RAD51 activity can cause genome instability. RADX is a single-strand D...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Adolph, Madison B., Mohamed, Taha M., Balakrishnan, Swati, Xue, Chaoyou, Morati, Florian, Modesti, Mauro, Greene, Eric C., Chazin, Walter J., Cortez, David
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935748/
https://ncbi.nlm.nih.gov/pubmed/33453169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.036
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