Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation

During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-dependent pathway and the generation of A/T mutations by the Msh2/ubiquitinated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Krijger, Peter H.L., Langerak, Petra, van den Berk, Paul C.M., Jacobs, Heinz
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2009
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806606/
https://ncbi.nlm.nih.gov/pubmed/19901081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091707
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