PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Both the programmed death (PD) 1–PD-ligand (PD-L) pathway and regulatory T (T reg) cells are instrumental to the maintenance of peripheral tolerance. We demonstrate that PD-L1 has a pivotal role in regulating induced T reg (iT reg) cell development and sustaining iT reg cell function. PD-L1(−/−) ant...

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Bibliografiska uppgifter
Huvudupphovsmän: Francisco, Loise M., Salinas, Victor H., Brown, Keturah E., Vanguri, Vijay K., Freeman, Gordon J., Kuchroo, Vijay K., Sharpe, Arlene H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806460/
https://ncbi.nlm.nih.gov/pubmed/20008522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090847
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