The PD-L1:B7-1 pathway restrains diabetogenic effector T cells in vivo

PD-L1 is a co-inhibitory molecule that negatively regulates multiple tolerance checkpoints. In the NOD mouse model PD-L1 regulates the development of diabetes. PD-L1 has two binding partners, PD-1 and B7-1, but the significance of the PD-L1:B7-1 interaction in regulating self-reactive T cell respons...

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Main Authors: Paterson, Alison M., Brown, Keturah E., Keir, Mary E., Vanguri, Vijay K., Riella, Leonardo V., Chandraker, Anil, Sayegh, Mohamed H., Blazar, Bruce R., Freeman, Gordon J., Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148082/
https://ncbi.nlm.nih.gov/pubmed/21697456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003496
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