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Role of PD-1 in regulating acute infections

While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by “helpless” CD8 memory T cells. An emerging r...

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Detalhes bibliográficos
Main Authors: Brown, Keturah E., Freeman, Gordon J., Wherry, E. John, Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905659/
https://ncbi.nlm.nih.gov/pubmed/20427170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2010.03.007
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