The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence

Oncogene-induced senescence acts as a barrier against tumour formation and has been implicated as the mechanism preventing the transformation of benign melanocytic lesions that frequently harbour oncogenic B-RAF or N-RAS mutations. In the present study we systematically assessed the relative importa...

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Main Authors: Haferkamp, Sebastian, Tran, Sieu L, Becker, Therese M, Scurr, Lyndee L, Kefford, Richard F, Rizos, Helen
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806033/
https://ncbi.nlm.nih.gov/pubmed/20157537
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