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p16(INK4a)-induced senescence is disabled by melanoma-associated mutations
The p16(INK4a)-Rb tumour suppressor pathway is required for the initiation and maintenance of cellular senescence, a state of permanent growth arrest that acts as a natural barrier against cancer progression. Senescence can be overcome if the pathway is not fully engaged, and this may occur when p16...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582406/ https://ncbi.nlm.nih.gov/pubmed/18843795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00422.x |
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