The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16(INK4a)

BACKGROUND: CDKN2A/p16(INK4a )is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16(INK4a )inhibits pRb phosphorylation and induces cell cycle arrest, which is considered its main tumour suppressor function. Nevertheless, additional...

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Détails bibliographiques
Auteurs principaux: Becker, Therese M, Haferkamp, Sebastian, Dijkstra, Menno K, Scurr, Lyndee L, Frausto, Monika, Diefenbach, Eve, Scolyer, Richard A, Reisman, David N, Mann, Graham J, Kefford, Richard F, Rizos, Helen
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644676/
https://ncbi.nlm.nih.gov/pubmed/19149898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-4
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