p16(INK4a)-induced senescence is disabled by melanoma-associated mutations

The p16(INK4a)-Rb tumour suppressor pathway is required for the initiation and maintenance of cellular senescence, a state of permanent growth arrest that acts as a natural barrier against cancer progression. Senescence can be overcome if the pathway is not fully engaged, and this may occur when p16...

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Huvudupphovsmän: Haferkamp, Sebastian, Becker, Therese M, Scurr, Lyndee L, Kefford, Richard F, Rizos, Helen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2008
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582406/
https://ncbi.nlm.nih.gov/pubmed/18843795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00422.x
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