The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects

AIMS: This study evaluated the effects of sitaxentan on the pharmacodynamic [systemic blood pressure (BP)] and pharmacokinetic (PK) parameters of sildenafil in healthy volunteers. METHODS: Healthy subjects (18–60 years, n= 24) were randomized into two sequence groups. Group 1 received sitaxentan sod...

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Bibliographic Details
Main Authors: Stavros, Fiona, Kramer, William G, Wilkins, Martin R
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
Subjects:
Pharmacokinetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805874/
https://ncbi.nlm.nih.gov/pubmed/20078609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03541.x
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