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Structural characterization of the core of the paired helical filament of Alzheimer disease.

The paired helical filament, the principal constituent of the neurofibrillary tangles characteristic of Alzheimer disease, is shown to consist of two structurally distinct parts. An external fuzzy region can be removed by Pronase treatment to leave a Pronase-resistant morphologically recognizable co...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Wischik, C M, Novak, M, Edwards, P C, Klug, A, Tichelaar, W, Crowther, R A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1988
Konular:
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280541/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2455299/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.13.4884
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