Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

Screening of cDNA libraries prepared from the frontal cortex of an Alzheimer disease patient and from fetal human brain has led to isolation of the cDNA for a core protein of the paired helical filament of Alzheimer disease. The partial amino acid sequence of this core protein was used to design syn...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Goedert, M, Wischik, C M, Crowther, R A, Walker, J E, Klug, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3131773/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.11.4051
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