Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

Screening of cDNA libraries prepared from the frontal cortex of an Alzheimer disease patient and from fetal human brain has led to isolation of the cDNA for a core protein of the paired helical filament of Alzheimer disease. The partial amino acid sequence of this core protein was used to design syn...

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Bibliographic Details
Main Authors: Goedert, M, Wischik, C M, Crowther, R A, Walker, J E, Klug, A
Format: Artigo
Language:Inglês
Published: 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC280359/
https://ncbi.nlm.nih.gov/pubmed/3131773
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