Structural characterization of the core of the paired helical filament of Alzheimer disease.

The paired helical filament, the principal constituent of the neurofibrillary tangles characteristic of Alzheimer disease, is shown to consist of two structurally distinct parts. An external fuzzy region can be removed by Pronase treatment to leave a Pronase-resistant morphologically recognizable co...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Wischik, C M, Novak, M, Edwards, P C, Klug, A, Tichelaar, W, Crowther, R A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280541/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2455299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.13.4884
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