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Structural characterization of the core of the paired helical filament of Alzheimer disease.

The paired helical filament, the principal constituent of the neurofibrillary tangles characteristic of Alzheimer disease, is shown to consist of two structurally distinct parts. An external fuzzy region can be removed by Pronase treatment to leave a Pronase-resistant morphologically recognizable co...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Wischik, C M, Novak, M, Edwards, P C, Klug, A, Tichelaar, W, Crowther, R A
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1988
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280541/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2455299/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.13.4884
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