Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates

Degradation by the ubiquitin-proteasome system requires assembly of a polyubiquitin chain upon substrate. However, the structural and mechanistic features that enable template-independent processive chain synthesis are unknown. We show that chain assembly by ubiquitin ligase SCF and ubiquitin-conjug...

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Bibliographic Details
Main Authors: Kleiger, Gary, Saha, Anjanabha, Lewis, Steven, Kuhlman, Brian, Deshaies, Raymond J.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804849/
https://ncbi.nlm.nih.gov/pubmed/19945379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.030
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