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Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation
Conjugation of ubiquitin-like protein Nedd8 to cullin (i.e. neddylation) is essential for the function of cullin-RING ubiquitin ligases (CRLs). Here we show that neddylation stimulates recruitment of ubiquitin-conjugating enzyme (E2) esterified with ubiquitin (E2~Ub), helps bridge the ~50 Å gap betw...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644375/ https://ncbi.nlm.nih.gov/pubmed/18851830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.021 |
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