The Steady-State Repertoire of Human SCF Ubiquitin Ligase Complexes Does Not Require Ongoing Nedd8 Conjugation

The human genome encodes 69 different F-box proteins (FBPs), each of which can potentially assemble with Skp1-Cul1-RING to serve as the substrate specificity subunit of an SCF ubiquitin ligase complex. SCF activity is switched on by conjugation of the ubiquitin-like protein Nedd8 to Cul1. Cycles of...

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Detalhes bibliográficos
Main Authors: Lee, J. Eugene, Sweredoski, Michael J., Graham, Robert L. J., Kolawa, Natalie J., Smith, Geoffrey T., Hess, Sonja, Deshaies, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
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Special Issue
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098594/
https://ncbi.nlm.nih.gov/pubmed/21169563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.006460
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