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Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

A ubiquitin-like modifier, NEDD8, is covalently attached to cullin-family proteins, but its physiological role is poorly understood. Here we report that the NEDD8-modifying pathway is essential for cell viability and function of Pcu1 (cullin-1 orthologue) in fission yeast. Pcu1 assembled on SCF ubiq...

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Udgivet i:EMBO J
Principais autores: Osaka, Fumio, Saeki, Mihoro, Katayama, Satoshi, Aida, Noriko, Toh-e, Akio, Kominami, Kin-ichiro, Toda, Takashi, Suzuki, Toshiaki, Chiba, Tomoki, Tanaka, Keiji, Kato, Seishi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313942/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880460/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.13.3475
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