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Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination
How do the cullins, with conserved structures, accommodate substrate-binding proteins with distinct shapes and sizes? Cullin-RING E3 ubiquitin ligases facilitate ubiquitin transfer from E2 to the substrate, tagging the substrate for degradation. They contain substrate-binding, adaptor, cullin, and R...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220518/ https://ncbi.nlm.nih.gov/pubmed/21937436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.277236 |
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