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The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation

In cullin-RING E3 ubiquitin ligases, substrate binding proteins, such as VHL-box, SOCS-box or the F-box proteins, recruit substrates for ubiquitination, accurately positioning and orienting the substrates for ubiquitin transfer. Yet, how the E3 machinery precisely positions the substrate is unknown....

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Detalhes bibliográficos
Main Authors: Liu, Jin, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741574/
https://ncbi.nlm.nih.gov/pubmed/19798438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000527
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