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Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases
Tagging proteins by polyubiquitin is a key step in protein degradation. Cullin-RING E3 ubiquitin ligases (CRLs) facilitate ubiquitin transfer from the E2 conjugating enzyme to the substrate; yet, crystallography indicates a large distance between the E2 and the substrate, raising the question of how...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824043/ https://ncbi.nlm.nih.gov/pubmed/20083119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.022 |
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