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Essential role for ubiquitin–ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate

During ubiquitin conjugation, the thioester bond that links ‘donor’ ubiquitin to ubiquitin-conjugating enzyme (E2) undergoes nucleophilic attack by the ε-amino group of an acceptor lysine, resulting in formation of an isopeptide bond. Models of ubiquitination have envisioned the donor ubiquitin to b...

Полное описание

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Библиографические подробности
Главные авторы: Saha, Anjanabha, Lewis, Steven, Kleiger, Gary, Kuhlman, Brian, Deshaies, Raymond J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091889/
https://ncbi.nlm.nih.gov/pubmed/21474069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.016
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