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Essential role for ubiquitin–ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate
During ubiquitin conjugation, the thioester bond that links ‘donor’ ubiquitin to ubiquitin-conjugating enzyme (E2) undergoes nucleophilic attack by the ε-amino group of an acceptor lysine, resulting in formation of an isopeptide bond. Models of ubiquitination have envisioned the donor ubiquitin to b...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091889/ https://ncbi.nlm.nih.gov/pubmed/21474069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.016 |
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