Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management

BACKGROUND: Lynch syndrome (LS) is associated with a high risk for colorectal cancer (CRC) and extracolonic malignancies, such as endometrial carcinoma (EC). The risk is dependent of the affected mismatch repair gene. The aim of the present study was to calculate the cumulative risk of LS related ca...

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Detalhes bibliográficos
Main Authors: Ramsoekh, Dewkoemar, Wagner, Anja, van Leerdam, Monique E, Dooijes, Dennis, Tops, Carli MJ, Steyerberg, Ewout W, Kuipers, Ernst J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804564/
https://ncbi.nlm.nih.gov/pubmed/20028567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-7-17
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