Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management

BACKGROUND: Lynch syndrome (LS) is associated with a high risk for colorectal cancer (CRC) and extracolonic malignancies, such as endometrial carcinoma (EC). The risk is dependent of the affected mismatch repair gene. The aim of the present study was to calculate the cumulative risk of LS related ca...

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Detaylı Bibliyografya
Asıl Yazarlar: Ramsoekh, Dewkoemar, Wagner, Anja, van Leerdam, Monique E, Dooijes, Dennis, Tops, Carli MJ, Steyerberg, Ewout W, Kuipers, Ernst J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2009
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804564/
https://ncbi.nlm.nih.gov/pubmed/20028567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-7-17
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