The PREMM(1,2,6) Model Predicts Risk of MLH1, MSH2, and MSH6 Germline Mutations Based on Cancer History

BACKGROUND & AIMS: We developed and validated a model to estimate the risks for mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6 based on personal and family history of cancer. METHODS: Data were analyzed from 4539 probands tested for mutations in MLH1, MSH2, and MSH6. A multiva...

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Bibliographic Details
Main Authors:	Kastrinos, Fay, Steyerberg, Ewout W., Mercado, Rowena, Balmaña, Judith, Holter, Spring, Gallinger, Steven, Siegmund, Kimberly D., Church, James M., Jenkins, Mark A., Lindor, Noralane M., Thibodeau, Stephen N., Burbidge, Lynn Anne, Wenstrup, Richard J., Syngal, Sapna
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3125673/ https://ncbi.nlm.nih.gov/pubmed/20727894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.08.021
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The PREMM(1,2,6) Model Predicts Risk of MLH1, MSH2, and MSH6 Germline Mutations Based on Cancer History

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